GPT and Hepatic fibrosis: As shown in Fig. 3 and Additional file 1: Fig. S5, the BDL group mice developed serious hepatic fibrosis, while lnc-Helf silencing alleviated BDL-induced hepatic fibrosis and inflammation as demonstrated by H&E staining, Masson staining, Sirius red staining, serum ALT, AST level, liver hydroxyproline content, western blot, and qRT–PCR (Fig. 3A–E; Additional file 1: Fig. S5A–D).