Moreover, we found that nuclear-retained lncRNA SCARNA10, which has human and mouse homology, is upregulated in serum of patients with liver fibrosis and functions as a positive regulator of liver fibrosis by suppressing polycomb repressive complex 2 (PRC2) and interacts with the promoters of ECM genes [16]. This evidence concerns the gene MMRN1 and Hepatic fibrosis.