TF and systemic lupus erythematosus: In the case of the SNPs with negative ΔMOCCS2scores (the SNPs that potentially enhanced TF binding specificities), SLE GWAS-SNPs exhibited low ΔMOCCS2scores (ΔMOCCS2score < –100) when they overlapped with the peaks in ChIP-seq samples of the blood cell type class, accounting for 84% of the 50 SNP-ChIP-seq pairs (Fig. 6B, right).