Lai et al., also considered the number of osteoblasts with Beclin-1 + , a marker of the autophagic process [23], whereas Yang et al. analyzed hypoxia-induced mitophagy in osteoblasts in the presence of PTEN-induced kinase 1 (PINK-1) in these cells in AP [25]. The gene discussed is PINK1; the disease is alkaline phosphatase measurement.