Prion diseases are a group of transmissible neurodegenerative diseases primarily caused by the conformational conversion of PrP from α-helix-dominant PrPC to β-sheet-rich PrPSc in many mammalian species (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12). Here, PRNP is linked to prion disease.