IQGAP2 and diabetes mellitus: Here, we investigate IQGAP2’s role in hepatic metabolism (fed versus fasted state) since SNP variants of the human IQGAP2 gene are associated with diabetes mellitus (19), and the IQGAP2 knockout (Iqgap2−/−) mouse model showed perturbed metabolic homeostasis with altered hepatic fatty acid uptake and lipid processing (20, 21).