Noteworthy, recent results of ours demonstrated that TXNL1 was the most rapidly and efficiently downregulated protein (among more than 8000 proteins analyzed in a comprehensive proteomic analyses) when cultured cancer cells were treated with auranofin [25], and others have also confirmed that TXNL1 is uniquely downregulated by auranofin treatment [26]. This evidence concerns the gene TXNL1 and cancer.