MYC, FAT1, NF-κB, TNF-α, and TP63 have been shown to be cancer-related genes and are all associated with the tumor-promoting effects of PADI4 (Zheng et al. 2016b; Park et al. 2015; Duffy et al. 2021; DiDonato et al. 2012; Srivastava et al. 2018) Therefore, we hypothesized that anti-PADI4 antibody could inhibit the expression of MYC, FAT1, NFκB, TNF-α, and TP63 genes by inhibiting cell membrane PADI4, which could inhibit tumor growth, metastasis, and glycolysis. This evidence concerns the gene NFKB1 and cancer.