In the present study, the results of liver transcriptomics showed that QAFEO significantly affected the response to LPS and TLRs signaling pathway, and down-regulated the expression of genes such as Cd14, Tnf-α, Ccl4. These results suggest that the effect of QAFEO in inhibiting liver inflammation may be related to the influence of LPS-mediated inflammatory signaling pathway. The gene discussed is CCL4; the disease is Hepatitis.