The observed significant association between specific somatic BRCA1 PVs namely, c.1961dupA and c.3329dupA in CRC patients in our results align with previous studies that have documented significant associations among these BRCA1 PVs not only in breast cancer cases [46, 48] but also in ovarian cancer contexts [49, 50]. This evidence concerns the gene BRCA1 and colorectal carcinoma.