For the T1w-based model, the dominant regions of influence on remote parts of the brain were in the temporal, parietal and occipital lobes, correlating to areas of characteristic tau deposition and areas of significant regional volume loss in the Alzheimer’s disease spectrum.4 Similar to the FDG-based model, the T1w model utilized the global information to predict the tau level; however, applying the model did not improve the performance compared to cortical thickness. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.