MAPT and Alzheimer disease: Figure 6A–D shows the meta-ROI tau-PET SUVR for each diagnostic subgroup. In addition, the scatter plots comparing the ground-truth versus AI-imputed SUVR has been visualized in Supplementary Fig. 1, 5. In general, the pattern of distribution was similar across the modalities, while the T1w-based tau-PET showed relatively lower predicted SUVR than others (Fig. 6C). The classification was performed for CU versus AD-spectrum, AD-spectrum versus FTD-spectrum and AD-spectrum versus DLB-spectrum (Fig. 6E–G).