The primary sensorimotor cortex and frontal lobe were dominant areas of influence on synthesized tau-PET accuracy from the FDG-based model revealed by occlusion analysis, surprising because the sensorimotor cortex is typically spared from FDG hypometabolism and frontal lobe involved in later stages of Alzheimer’s dementia.77 Therefore, preserved metabolism in these regions may be interpreted by the model as reference region, modifying the model’s prediction of tau uptake in remote locations of the brain. Here, MAPT is linked to Alzheimer disease.