For the AD-spectrum versus FTD-spectrum, the PiB-based model showed the best performance followed by the actual, FDG-based and T1W-based tau-PET (Fig. 6F); however, the PiB-PET also performed well and was not significantly different with the synthesized tau-PET (P = 0.65, Holm-Sidak test, Fig. 6F). The gene discussed is MAPT; the disease is frontotemporal dementia.