For stroke robust associations were observed for genetic predisposition to several thrombotic factors, apolipoprotein B (IVW OR: 1.14, 95%CI: 1.07 - 1.22) and urinary sodium excretion (IVW OR: 1.6, 95%CI: 1.12 - 2.3) (positive) and IL6R (IVW OR: 0.92, 95%CI: 0.85 - 0.98) and transferrin (IVW OR: 0.82, 95%CI: 0.70 - 0.96) (inverse). The gene discussed is IL6R; the disease is Stroke.