For CAD, these included the well-established cardiovascular risk factors such as blood pressure, type 2 diabetes, obesity, smoking and cholesterol levels but also, anthropometry and physical measurements (height, birth weight, muscular strength and FVC) and several biomarkers (leucocyte count, serum calcium, IL6R signaling, protein C, omega 6 fatty acid levels, sex hormone binding globulin). This evidence concerns the gene SHBG and obesity due to melanocortin 4 receptor deficiency.