MLX and Parkinson disease: To further establish the importance of the nominated genes in PD, we examined whether they are differentially expressed in PD patients compared to controls, using expression data from single nuclear RNAseq (scRNA) from Kamath et al. 12 and single nuclear and bulk RNAseq datasets from FOUNDIN-PD.15 Of the top nominated genes, INPP5F [average log fold-change (FC) = −7.22, P = 2.90 × 10−31] and MLX (average log FC = −1.80, P = 2.23 × 10−4) were associated with PD in the data published by Kamath et al. 12 (Supplementary Table 6).