Rs665268 is a missense variant (p.Gln139Arg) that was found to be associated with Takayasu’s arteritis, an autoimmune systemic vasculitis.55MLX was also reported to be associated with age at onset of Alzheimer’s disease in females.56 This variant was suggested to affect two important PD pathways by increasing oxidative stress and suppressing autophagy in immune cells.55,56SPNS1 and MLX have not previously been implicated in PD. This evidence concerns the gene MLX and early-onset autosomal dominant Alzheimer disease.