BACE1 and Parkinson disease: IP6 has a neuroprotective effect on dopaminergic cells by preventing 6-OHDA-induced apoptosis.45 IP6 inhibits the activity of β-secretase 1 (BACE1), an enzyme that cleaves amyloid-β precursor protein into toxic amyloid-β peptides.46 Paraquat-induced neurodegeneration in Drosophila was suggested to increase the levels of inositol phosphates metabolites.47 Previous studies have also suggested that different stereoisomers of inositol such as scyllo-inositol can inhibit the aggregation of α-synuclein48 or decrease the myoinositol concentration in patients with PD.49,50