In FOUNDIN-PD,15 after excluding prodromal cases, we found differential expression of many genes including INPP5F (average log FC = 0.070, P = 1.89 × 10−19) and IP6K2 (average log FC = −0.076, P = 1.35 × 10−35) in scRNA data (n = 80) from dopaminergic neurons by comparing PD and controls (Supplementary Table 7). The gene discussed is IP6K2; the disease is Parkinson disease.