In neuroblastoma cells, ITPKB mRNA levels were also shown to be correlated with SNCA expression in the cortex and IPTKB protein levels were increased in wild-type α-synuclein, A53T and A30P mutants.38 Meanwhile, IP6K2 and PPIP5K2 interact with the same substrates. The gene discussed is ITPKB; the disease is neuroblastoma.