GSTM1 and malaria: These include structural variants of adult hemoglobin (HbA; wild type) involving a single point mutation within codon 6 of the β-globin as in hemoglobin (Hb) S and C. Heterozygous carriers (HbAS or HbAC) are highly protected against severe malaria but not from P. falciparum infection [1], suggesting a multifactorial protection.