In this review, Medline, Current Contents, the Cochrane Library, Google Scholar, and PubMed were searched without date restriction using a wide range of search terms: “RNA binding protein,” “RNA binding proteins,” “RNA‐binding protein,” “RNA‐binding proteins,” “RBPs,” “RBP” AND “intervertebral disc degeneration,” “IVD,” “IDD,” “IVDD” AND “osteoarthritis,” and “OA.” Only English‐language references were included in this review. The gene discussed is RBMS3; the disease is Intervertebral disk degeneration.