We will discuss three aspects in this section: the roles of specific RBPs (HuR, TTP, FUS, YTHDF2, YTHDC2, KRT18, GNL3, CIRBP, RBPMS, and RBMS3) in RNA metabolism; dysregulation of these RBPs in IDD and OA; and their contribution to the development of IDD and OA. The gene discussed is CIRBP; the disease is intervertebral disk degenerative disorder.