HEPES also has potential for a myriad of clinical applications [51], including the inhibition of the conversion of prion proteins in cell culture [52], the increase of glucocerebrosidase (GCase) activity in Gaucher disease‐patient derived fibroblasts [53], and the protection of myocardial tissue in immature myocardial ischemia–reperfusion injury [54], which are all cell‐protective functions. The gene discussed is GBA1; the disease is myocardial ischemia.