Accordingly, a relative increase of certain markers can be detected in the profile of cancer cell-derived EVs compared with normal primary astrocyte-EVs: CD44 and CD90 were elevated in LN18-EVs; CD36, CD54, CSPG4, and GD2 in LN229-EVs; CD13, CD49e, CD49f, and CD90 in NCH82-EVs. This evidence concerns the gene ITGA5 and cancer.