EV Neuro signal intensity analysis for CD63+EVs and CD81+EVs revealed a large signal variation in MS patient and control EV samples for all analyzed markers despite constant underlying plasma sample input per EV Neuro panel (250 μl), indicating high interindividual variation independent of disease state ([upper graphs in Fig. 5a (CD63+EVs) and b (CD81+EVs)]. The gene discussed is CD81; the disease is myeloid sarcoma.