Depending on the location and stage of the ROP, intravitreal vascular endothelial growth factor (VEGF) inhibitor or laser ablation of non-vascularized retinal areas reduces the risk of blindness related to ROP have shown satisfactory outcomes, still some treated infants do not achieve good long-term visual acuity due to several other complications related to the disease. This evidence concerns the gene VEGFA and blindness (disorder).