NPM1 and neoplasm: Genes commonly mutated in AML can be grouped into 8 different categories which include 1) genes involved in signal transduction 2), tumor suppressors, 3) genes responsible for DNA methylation and 4) chromatin modifications, 5) myeloid transcription factors, 6) nucleophosmin, 7) genes related to the spliceosome complex, and 8) to the cohesine complex (Table 2).