Furthermore, while the Del5|2 mutation of Lkb1 changed little with the frequency at about 40% among all tumor cells tested, the Lkb1 Ins1G mutation oscillated significantly among these tumor cells, with the frequency at about 40% in SG1-1, SG1-2, SG2-5, and SG2-6 as well as 1C3-1 but nearly undetectable in SG4-1, SG4-3, SG5-1, and SG5-2 (Fig. 5D). This evidence concerns the gene STK11 and neoplasm.