SLC5A2 and heart failure: Furthermore, the recent guideline regulated by the American Heart Association (AHA), the American College of Cardiology (ACC), and the Heart Failure Society of America (HFSA) has recommended the administration of SGLT2 inhibitors in patients with HFrEF, HF with mildly reduced EF (HFmrEF), or HF with preserved ejection fraction (HFpEF) [4].