ZBTB16 and metastatic neoplasm: The IHC staining images of primary and metastatic tumor lesions from 5 representative OV patients were shown in Fig. 11C. Through IHC staining analysis of the tissue microarrays based on 125 OC cases, we found that ZBTB16 expression was increased among patients who suffered recurrence or death, compared with survivors (Fig. 11D).