Quantitative gene expression analysis revealed the increased expression of ferroptosis suppressor protein 1 (FSP1), alpha-1 subunit of the fibril-forming type I collagen (COL1A1), and fibroblast activation protein (FAP), suggesting that the high AGE diet resulted in fibroblasts assuming the phenotype of activated fibroblasts similar to that found in cancer-associated fibroblasts (Fig. 5C) [44]. This evidence concerns the gene FAP and cancer.