VEGFC and lobular neoplasia: However, Wang et al. [123] determined the intratumoral and peritumoral lymphatic vessel density by immunohistochemistry (IHC) and found that P-LVD was significantly correlated with LN metastasis, lymphatic invasion, VEGF-C, VEGF-D and VEGFR-3 expression in peritumoral tissues, and was an independent risk factor for LN metastasis, but there was no significant association between the above variations and I-LVD.