To conclude, we discovered that the ectopic upregulation of the otherwise very low expressed miRNA miR-4649-5p exerts tumor-suppressive effects on TNBC cells in vitro and that this may in part be ascribed to its direct target PIP5K1C, which is known to regulate migration, as well as PI3K/AKT signaling further downstream, which influences growth and proliferation. This evidence concerns the gene PIP5K1C and neoplasm.