In particular, Males Only DMRs selected by machine learning feature selection were able to distinguish CHD from non-CHD samples and frequently mapped to genes associated with CHDs or cardiomyopathies, including FUNDC1 [71], ETV5 [72, 73], SYT9 [74], CAMTA1 [75], GRIA4 [76], and IGF1R [77–80]. Here, SYT9 is linked to coronary artery disorder.