GATA1 and coronary artery disorder: Further, we previously reported a positive relationship between high nRBC proportions in newborns with DS and the presence of somatic GATA1 mutations, indicative of transient abnormal myelopoiesis (TAM) or silent TAM, and it is possible that the relationship between CHD and global hypomethylation in males may be confounded by this preleukemic condition [17].