We analyzed the TCGA-HNSCC dataset and multiple GEO HNSCC datasets, and we first demonstrated that CERCAM mRNA expression levels and total protein expression levels in HNSCC were overexpressed compared to normal tissues, which was consistent with the immunohistochemical staining results of CERCAM in HNSCC in the HPA database. The gene discussed is CERCAM; the disease is head and neck squamous cell carcinoma.