Based on this, we used the Timer database to explore the correlation between CERCAM expression and immune cell infiltration in HNSCC.As shown in Fig. 9, we found that the expression of CERCAM correlated most significantly with the infiltration of macrophages in tumors (Cor = 0.328, P = 1.5e-13), followed by CD4+ T cells (Cor = 0.243, P = 7.22e-8) and DC cells (Cor = 0.215, P = 1.81e-6). The gene discussed is CD4; the disease is head and neck squamous cell carcinoma.