Early in 2018, the author and her colleges have revealed that transcription factor STAT3 enhances lincRNA HOTAIR transcription by interacting with pEZH2-Serine21, instead of pEZH2-T487 in head and neck squamous cell carcinoma (HNSCC), thus promoting tumor progression and cisplatin resistance [20]. The gene discussed is STAT3; the disease is neoplasm.