Additionally, in multivariable Cox models, persistent PSA (Table 3) was an independent predictor for death (HR: 3.07, 95%-CI: 1.42–6.63, p < 0.01), after adjusting for preoperative PSA value, pathologic tumor stage, surgical margin status, lymph node status, pathologic Gleason Score and CCI. Here, KLK3 is linked to neoplasm.