KLK3 and neoplasm: Additionally, in multivariable Cox models, persistent PSA (Table 3) was an independent predictor for development of BCR (HR: 5.47, 95%-CI: 3.98–7.51, p < 0.001), after adjusting for preoperative PSA value, pathologic tumor stage, surgical margin status, lymph node status and pathologic Gleason Score.