Moreover, we provide new findings, where adverse pre- and perioperative tumor characteristics, namely higher preoperative PSA (OR 1.04), biopsy Gleason 8–10 (OR: 1.81), LNI (OR: 3.53), pathologic stage ≥T3b (OR: 1.74) as well as positive surgical margins (OR: 1.92), were independent predictors for development of PSA persistence after SRP. The gene discussed is KLK3; the disease is neoplasm.