One of the genes downregulated in association with MALAT1 was PIN1 that seems to be required for the transcriptional activity of wild-type TP5337, suggesting that the low levels of PIN1 found in CLL with high MALAT1 expression could contribute to impair TP53 activity even in absence of alterations in this tumor suppressor gene. Here, MALAT1 is linked to B-cell chronic lymphocytic leukemia.