Interestingly, our guilt-by-association analysis on the coding genes correlated with MALAT1 in CLL as well as the differentially expressed genes in cases with high and low MALAT1 revealed significant enrichment in genes signature highly expressed in nodal CLL17, and interleukin/cytokine-signalling27, suggesting a close relationship between MALAT1 expression and the influence of the nodal microenvironment. The gene discussed is MALAT1; the disease is B-cell chronic lymphocytic leukemia.