Other pathways identified were related to activation, proliferation, and survival of CLL cells in the lymph node (LN) microenvironment, particularly PI3K/AKT, MAPK, and signaling of several interleukins, among others18–22 (Fig. 3b, Supplementary Fig. S6a and Table S4 online). Here, AKT1 is linked to B-cell chronic lymphocytic leukemia.