This analysis confirmed pathways identified in the previous analysis of genes correlated with MALAT1 expression such as the signature highly expressed in nodal CLL and cell cycle regulation, as well as pathways related to regulation of proliferation and NF-kB activation, among others involved in CLL pathogenesis (Fig. 4a and Supplementary Table S9). This evidence concerns the gene MALAT1 and B-cell chronic lymphocytic leukemia.