Interestingly, we found that MALAT1 levels remained similar in PB compared to LN/BM paired CLL samples, supporting that the clinical value of MALAT1 expression found in PB is mirroring expression differences in other compartments as in the LN, and that could be associated with the degree of the microenvironment stimulation. This evidence concerns the gene MALAT1 and B-cell chronic lymphocytic leukemia.