We also evaluated the possible association of MALAT1 levels with other molecular factors previously shown to have prognostic value in CLL, such as mutations in driver genes, number of chromosomal aberrations13,14, IGLV3-21 variant/R110 mutation15, or the DNA methylation-based epiCMIT score related to the proliferative history of the tumor cells16. The gene discussed is MALAT1; the disease is B-cell chronic lymphocytic leukemia.