ENDOU and neoplasm: EndoU family of endonucleases have been implicated in many processes, including as a tumor biomarker in human beings77–79, immune response in mice51, ER morphology in Xenopus80, neurodegeneration in Drosophila50, cold tolerance, nucleotide metabolism, lifespan and germline immortality in C. elegans61,81,82, and viral replication and pathogenicity83–85.