BRCA2 and breast neoplasm: Sequencing of another set of gBRCA1/2mut breast tumors also showed high incidence of locus-specific LOH for BRCA1 (90%); however, lower LOH incidence (54%) was observed for BRCA2. In that dataset, LOH for BRCA1 was more commonly copy neutral and loss of the wildtype allele more frequent in gBRCA2mut tumors16.