JUN and breast cancer: In contrast to the c-Jun wild-type construct, the c-Jun S63A mutant form failed to promote CPT1A expression at either the mRNA or protein level (Fig. 5c, d and Supplementary Fig. 5c, d); furthermore, the c-Jun S63A mutant failed to increase ATP production and the FAO rate in ER-positive BC cells (Fig. 5e, f and Supplementary Fig. 5e, f).