Next, we orthogonally validated the observed protective phenotypes of inactivated NFKBIA, EIF4E2, and EIF4H by generating knockout lines from Huh7.5.1 (hepatocellular carcinoma) cells ectopically expressing ACE2 and TMPRSS2 (Fig. 3B). Here, EIF4E2 is linked to hepatocellular carcinoma.