CXCR3 and infection: The long-lived antibody response is mainly supported by TFH cells in natural infection and vaccination.47,64 We found that SARS-CoV-2 infection and vaccination induced a persistent spike-specific TFH cell responses, consistent with other studies, thus laying the foundation for long-term immunity.61,62 Notably, spike-specific TFH cells, especially spike-specific CXCR3+ TFH cells, positively correlated with antibody responses at 5 months in convalescents, and the quantity and quality of the antibodies were well balanced.