Similar to CML, reduced expression of CaSR on LIC in B-ALL22 resulted in a significant increase in leukocytes (Supplementary Fig. 9d), the percentage of BCR-ABL1+ BP1+ pre-B cells (Supplementary Fig. 9e) and significantly shortened survival (Supplementary Fig. 9f). Here, ABL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.