In sharp contrast, CaSR overexpression in CML LIC (Supplementary Fig. 10d) led to a trend towards a decrease of the leukocyte count (Supplementary Fig. 10e) and a reduced percentage of BCR-ABL1+ CD11b+ leukocytes in PB (Supplementary Fig. 10f), as well as significant survival prolongation (P = 0.0156, Fig. 3d). This evidence concerns the gene ITGAM and chronic myelogenous leukemia, BCR-ABL1 positive.