Immunophenotyping (Supplementary Fig. 11a) of WT, CaSR KO or CaSR OE MLL-AF9+ Gr1+ myeloid cells26 revealed varying expression levels of Gr1, whereby the Gr1 low population morphologically correlated with a higher blast/neutrophil ratio compared to the Gr1 high population, consistent with an increased percentage of blasts and higher AML severity27 (Supplementary Fig. 11b). This evidence concerns the gene KMT2A and acute myeloid leukemia.