Consistently, MLL-AF9+ CaSR KO AML cells, exhibited a reduced percentage of Gr1 low cells (Supplementary Fig. 11c), while CaSR OE leukaemia cells were characterised by a higher percentage of this blast-enriched Gr1 low population (Supplementary Fig. 11d). The gene discussed is KMT2A; the disease is acute myeloid leukemia.