CASR and acute myeloid leukemia: Immunophenotyping (Supplementary Fig. 11a) of WT, CaSR KO or CaSR OE MLL-AF9+ Gr1+ myeloid cells26 revealed varying expression levels of Gr1, whereby the Gr1 low population morphologically correlated with a higher blast/neutrophil ratio compared to the Gr1 high population, consistent with an increased percentage of blasts and higher AML severity27 (Supplementary Fig. 11b).