CASR and leukemia: Given these findings on calcium and the recently discovered role of the local concentration of another chemical factor in the BMM, adenosine triphosphate (ATP), on LSC in acute myeloid leukaemia (AML)19, we hypothesised that calcium ions released from remodelling bone, subject to a fine balance between osteoblasts and osteoclasts, and/or CaSR, may contribute to leukaemia development, progression and response to therapy.