Plating of CaSR KO BM (P = 0.0337, Fig. 3h) or spleen (P = 0.0444, Fig. 3i) cells from mice with established MLL-AF9+ AML in methylcellulose gave rise to significantly less colonies compared to controls, whereby similar results were observed after replating (Fig. 3j). This evidence concerns the gene MLLT3 and acute myeloid leukemia.