Plating of CaSR KO BM (P = 0.0337, Fig. 3h) or spleen (P = 0.0444, Fig. 3i) cells from mice with established MLL-AF9+ AML in methylcellulose gave rise to significantly less colonies compared to controls, whereby similar results were observed after replating (Fig. 3j). This evidence concerns the gene KMT2A and acute myeloid leukemia.