Consistently, a genome-wide transcriptome analysis revealed overall 497 up- and 299 downregulated differentially expressed genes (DEG) between WT versus CaSR OE MLL-AF9+ Lin− cells, in particular showing an upregulation of several homeobox (HOX) genes in CaSR-overexpressing LIC (Fig. 3l), known to increase self-renewal potential and promote AML development29,30. Here, LBX1 is linked to acute myeloid leukemia.