Transplantation of CaSR-deficient sorted Lin− MLL-AF9+ (GFP+) LIC from primary mice with established AML led to a reduction in leukocytes (Supplementary Fig. 13a, b), the percentage of MLL-AF9+ Gr1+ cells in PB of secondary recipient mice (Supplementary Fig. 13c) and to prolongation of survival compared to controls receiving WT LIC (P = 0.0306, Fig. 3f). The gene discussed is MLLT3; the disease is acute myeloid leukemia.