Complementarily, overexpression (OE) of CaSR by co-transduction of LIC with CaSR- or empty vector-expressing retrovirus, led to an increased leukocyte count (Supplementary Fig. 10a, b) and percentage of MLL-AF9+ Gr1+ cells (Supplementary Fig. 10c), as well as shortened survival of WT recipients with AML (P = 0.0021, Fig. 3c). The gene discussed is CASR; the disease is acute myeloid leukemia.