ANO2 and myeloid sarcoma: CSF serological analysis revealed cross-reactivity between a glial cell adhesion molecule and another EBNA1 epitope in 20%–25% of patients with MS.39 T-cell immunity depends on other EBV epitopes, and HLA-restricted CD4+T cells might be primed against two EBV-specific peptides and the CNS antigen RASGRP2.40 ANO2, a chloride channel protein that is important in several cell types and expressed in glial cells and neurons, has recently been investigated as an autoantigen in MS.