Plasma antibody assays and absorption tests have uncovered an EBNA1 epitope that cross-reacts with the central nervous system protein anoctamin 2 (ANO2) in 14.6% of patients with MS and 7.8% of controls.15 16 Reactivity to a similar EBNA1 peptide was reported as part of polyspecific autoimmunity during acute IM.17 18. The gene discussed is ANO2; the disease is myeloid sarcoma.