IL2 and colitis: Besides those discussed, other therapies have also been applied for the treatment of ICI colitis, such as calcineurin inhibitors (CNIs; tacrolimus and cyclosporine), tocilizumab, and mycophenolate mofetil (MMF).111 Tacrolimus has been recommended by the British Society of Gastroenterology (BSG) and the European Society for Medical Oncology (ESMO) for ICI colitis, thanks to its activity of suppression cytokine release such as IL-2, TNF-α, and IFN-γ, inhibiting T-cell activation.112