This correlation was unaffected by steroid treatment history, and supports previous reports of TREM-1 activation modulating the function of neutrophils in models of IBD.18 While faecal calprotectin has been related to anti-TNF response and is usually monitored in clinical practice,19,20 we did not find a strong correlation between TREM-1 expression and absolute baseline or change from baseline in faecal calprotectin levels. The gene discussed is TNF; the disease is inflammatory bowel disease.