Zenaro et al. identified that in two transgenic models of Alzheimer’s disease (5xFAD and 3xTg-AD mice), neutrophil infiltration and localization within amyloid-beta (Aβ) deposits were accompanied by the release of neutrophil extracellular traps (NETs) and IL-17. The gene discussed is IL17A; the disease is early-onset autosomal dominant Alzheimer disease.