ERBB2 and breast cancer: Using the GEO2R platform [62] and the limma (Linear Models for Microarray Analysis) R package, we analyzed the expression array GSE129254 [55] dataset for differentially expressed genes (DEGs) comparing HER2-positive SKBR3 and BT474 breast cancer cell lines treated with DMSO or the selective ATP-competitive tyrosine kinase inhibitor (TKI), lapatinib, an anti-HER2 therapy [55].