Specifically, the TFIIIB subunits TBP [24–26], BRF1 [6, 27–29], BRF2 [6, 7, 30–37], and BDP1 [8, 9, 12, 21, 38, 39] are altered in a variety of human cancers, including breast, blood, colorectal, cervical, esophageal, liver, lung, prostate, and skin cancers. This evidence concerns the gene BDP1 and skin neoplasm.