Patients with COVID-19 mount an early and robust defense through the activation of type 1 and 2 interferon (IFN) responses, which are pivotal against viral infections.40,41 Nevertheless, studies40,41 indicate that these IFN responses may also induce hyperinflammation, exacerbate the severity of COVID-19, and be associated with mortality. This evidence concerns the gene IFNA1 and COVID-19.