Methylation of the promoter region of PXDN appears to suppress transcription and is negatively correlated with PXDN expression in cancers of the liver, breast, skin, kidney, oesophagus, thyroid, rectum, lung, bladder, stomach, bone, head and neck, colon, prostate, mesothelium, pancreas, uterus, cervix and ovary [22]. The gene discussed is PXDN; the disease is cancer.