ITIH4 and Anxiety: Although direct conclusions about anxiety cannot be made from the non-specific locomotor activity measured in this study, it is interesting that gp120 and TAF altered potential anxiety-related activity and that on a cellular level gp120 and TAF also induced the changes in CB1R (Fig. 1, Table 1), a receptor known to be involved in the neurobiology of anxiety (Petrie et al. 2021).