Alterations in CB1R and CB2R receptor expression has been found in a variety of neurodegenerative disorders (Swinton et al. 2021; Tadijan et al. 2022; Young and Denovan-Wright 2021), and increased CB1R expression is found in post-mortem frontal cortex of PWH on ART with minor neurocognitive dysfunction (MND) or HIV-associated dementia (HAD) but not in neurocognitively unimpaired (NUI) or asymptomatic neurocognitive impairment (ANI), with increases in CB1R expression being correlated with poorer cognitive function (Swinton et al. 2021). Here, CNR1 is linked to AIDS dementia complex.