CNR1 and asymptomatic neurocognitive impairment: Alterations in CB1R and CB2R receptor expression has been found in a variety of neurodegenerative disorders (Swinton et al. 2021; Tadijan et al. 2022; Young and Denovan-Wright 2021), and increased CB1R expression is found in post-mortem frontal cortex of PWH on ART with minor neurocognitive dysfunction (MND) or HIV-associated dementia (HAD) but not in neurocognitively unimpaired (NUI) or asymptomatic neurocognitive impairment (ANI), with increases in CB1R expression being correlated with poorer cognitive function (Swinton et al. 2021).