ITIH4 and peripheral neuropathy: Previous studies have demonstrated that at 12-months of age gp120 mice have loss of neuronal dendrites and synapses, increases in microgliosis (Iba1), astrogliosis (GFAP), reduced swimming velocity, impaired spatial retention memory, alterations in open field and activity measures, increases in peripheral neuropathy, but no significant impairment in motor function as measured by the rotarod test (D'Hooge et al. 1999; Thaney et al. 2018).