Interestingly, our data proved that the CD200 expression level was negatively associated with [18F]DPA-714 uptake in the HC and AD groups including the global SUVR (r =—0.330, P = 0.013) (Fig. 4E) and SUVRs of the frontal lobe, parietal lobe, temporal lobe, parahippocampal cortex, PCC, precuneus, striatum, amygdala, and white matter (P < 0.05) (Table S4). Here, CD200 is linked to Alzheimer disease.