Among them, the expression levels of APLNR, TGFBR3, CXCR4, GFAP, MAP3K5, and GJA1 were up-regulated in the AD group, whereas those of PSMD8, FABP3, CHGB, FGF12, UCHL1, COX5B, UBE2N, SYP, and CD200 were down-regulated in the AD group compared with those in the HC group (Table S3). The gene discussed is MAP3K5; the disease is Alzheimer disease.