ATP2A2 and myocardial infarction: While at the transcript level, Atp2a2 showed minor changes, Serca2a protein level was significantly lower in the ischemic (I) zone for MI vs. Sham animals yet there was no difference in Serca2a protein level for Treatment vs. Sham (Fig 8E), indicating a potentially higher risk for Ca2+-mediated triggered arrhythmias in MI animals.