We found significantly higher levels of CK (p = 3.4e−08), ALT (p = 1.8e−06) and AST (p = 0.02) in patients with spinal onset, while levels of serum creatinine were slightly increased in cases with bulbar-onset ALS (p = 3.6e−07; Table 1 and Supplementary Table S1). This evidence concerns the gene GPT and amyotrophic lateral sclerosis.