The injection of SPI-1 effectors, and primarily SipA, inside intestinal epithelial cells is required for Salmonella to fully induce the expression of chemokines like IL-8 that stimulates the inflammatory response by inducing polymorphonuclear neutrophilic leukocyte migration, ultimately leading to enteritis and diarrhea (33, 34). This evidence concerns the gene CXCL8 and enteritis.