We found that high NT5DC2 expression resulting in GC patients of lymph node metastasis (OS N1 + 2 + 3HR = 1.58, P = .00067; PPS HR = 1.71, P = .00024), GC patients of negative HER2 (OS negative HER2 HR = 1.71, P = 3.20E-06; PPS HR = 1.67, P = .00045), GC patients of positive HER2 (OS positive HER2 HR = 1.69, P = 6.90E-05; PPS HR = 2.26, P = 6.80E-06) and GC patients of intestinal (OS intestinal HR = 2.28, P = 3.80E-07; PPS HR = 2.53, P = 1.30E-05) had poor OS and PPS (Table 1). Here, ERBB2 is linked to metastatic malignant neoplasm in the lymph nodes.