It has been reported that in NSCLC, the NT5DC2 expression had positive correlation with p53 protein and TP53 gene expression and its survival effect for lung adenocarcinoma was p53 dependent.[20] However, p53 expression was up-regulated in NT5DC2 knockdown NSCLC cells.[13] Likewise, in GC, the p53 signaling pathway was inhibited by low expression of neuronal pentraxin II (NPTX2). The gene discussed is NPTX2; the disease is gastric cancer.