Recently, ferroptosis has been found to play an important role in breast cancer[10] and gastric cancer.[11] At the same time, it has also been verified to play biological roles in many nonneoplastic diseases, For example, Alzheimer[12] and cardiovascular disease.[13] The GPX4-GSH defense system is the most classic ferroptosis antioxidant defense system.[14] Furthermore, recent studies have confirmed that Frizzled-7 (FZD7) could promote ferroptosis through the β-catenin-TP63-GPX4 pathway in ovarian cancer.[15]. Here, FZD7 is linked to breast cancer.