INS and coronary artery disorder: Furthermore, several studies have found that the increased risk of macrovascular complications, especially coronary artery disease (CAD), is also closely related to NAFLD.[72–74] Mechanisms explaining this relationship include the regulation of insulin resistance by hepatic lipid accumulation, the release of pro-inflammatory, pro-oxidative, and pro-coagulant factors and profibrotic mediators in the bloodstream, oxidative stress and hypertension, which can promote myocardial remodeling and dysfunction, thereby inducing the occurrence of various cardiac complications.[73,75]